IFGH 2010: Molecular Analysis Of Msp1 And Msp2 Genotypes Of Plasmodium Falciparum Obtained From Adults Participating In The P. Falciparum Malaria Protein 10 (Fmp10) Vaccine Trial In Kombewa Division, Western Kenya

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November 30, 2010

Plasmodium falciparum is the most virulent species of the malaria parasites that infect humans. The parasite success is in part attributable to its extensive genetic diversity that allows circumnavigation of host immunological onslaught. Undoubtedly, the fight against malaria must include attempts to unravel the drivers of such extensive genetic polymorphisms.

In this study, malaria parasites were collected weekly for 112 days from cohorts taking part in a malaria vaccine trial. We report on temporal changes on the allelic diversity and complexity of the infecting P. falciparum strains collected from participants enrolled in that study. Our findings show capillary electrophoresis to be a highly sensitive technique that allows for the precise sizing and discrimination of MSP1 and MSP2 alleles and the observed temporal genetic changes were considered to reflect malaria transmission dynamics due to rainfall patterns and the implementation of interventions such as treatment with anti- malarial drugs.

 

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